The documents listed below provide information on regulations and guidelines regarding methadone dosing and safety. You can search them easily for specific information about the safety of methadone.
samhsa.gov – Methadone
https://www.samhsa.gov/medication-assisted-treatment/medications-counseling-related-conditions/methadone
3/3/2022, updated flexibility regs for methadone from SAMHSA
https://www.samhsa.gov/medication-assisted-treatment/statutes-regulations-guidelines/methadone-guidance
Principles of Drug Addiction Treatment: A Research-Based Guide (Third Edition)
https://d14rmgtrwzf5a.cloudfront.net/sites/default/files/675-principles-of-drug-addiction-treatment-a-research-based-guide-third-edition.pdf
Disposal of Unused Medicines: What You Should Know – FDA.gov
Learn how to dispose of unused or expired drugs
https://www.fda.gov/drugs/safe-disposal-medicines/disposal-unused-medicines-what-you-should-know
(DEA) – Drug Disposal Information
https://www.deadiversion.usdoj.gov/drug_disposal/index.html
Federal opioid treatment standards
https://www.govregs.com/regulations/expand/title42_chapterI_part8_subpartC_section8.12
The ASAM National Practice Guideline for the use of medications in the treatment of addiction involving opioid use
https://www.asam.org/docs/default-source/practice-support/guidelines-and-consensus-docs/asam-national-practice-guideline-supplement.pdf
Drug Interactions of Clinical Importance among the Opioids, Methadone and Buprenorphine, and other Frequently Prescribed Medications: A Review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334287/
QTc interval screening for cardiac risk in methadone treatment of opioid dependence – Pani, PP – 2013
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD008939.pub2/full
No Evidence to Support QTc-Interval Screening in Methadone Maintenance Treatment: Cochrane Review, July 2013, Addiction Treatment Forum.
https://atforum.com/2013/07/no-evidence-to-support-qtc-interval-screening-in-methadone-maintenance-treatment-cochrane-review/
FDA Drug Safety Communication: FDA urges caution about withholding opioid addiction medications from patients taking benzodiazepines or CNS depressants; careful medication management can reduce risks, September 20, 2017.
https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-urges-caution-about-withholding-opioid-addiction-medications
SAMHSA Dear Colleague Letter on State Prescription Drug Monitoring Programs (PDMPs),
September 27, 2011.
https://www.samhsa.gov/sites/default/files/programs_campaigns/medication_assisted/dear_colleague_letters/2011-colleague-letter-state-prescription-drug-monitoring-programs.pdf
Overdose Prevention and Take-Home Naloxone Projects
http://harmreduction.org/hrc2/wp-content/uploads/2020/08/Resource-OverdosePrevention-GuidetoDevelopingandManagingOverdosePreventionandTakeHomeNaloxoneProjects.pdf
2/10/2022, Markey bill to increase flexibility in methadone take-homes, pharmacy dispensing
https://www.markey.senate.gov/news/press-releases/senators-markey-and-paul-introduce-bipartisan-legislation-to-modernize-improve-methadone-treatment-amid-skyrocketing-opioid-overdoses-and-deaths