“Contrary to recent news reporting, there are no fentanyl analogues resistant to Naloxone. News reports indicated a “new” fentanyl analogue, acrylfentanyl, was “extremely powerful” and implied it resisted Naloxone’s effects.
However, acrylfentanyl binds to the same receptors within the human body as fentanyl, meaning correctly administered Naloxone is effective against it.”
Source: U.S. Department of Homeland Security – July 11, 2017
See related article on Fentanyl – How fentanyl is making deadly drugs even deadlier available at: http://www.popsci.com/fentanyl-could-be-making-opioid-drugs-even-deadlier