Genes Found That May Protect Infants Born to Addicted Mothers

“Genes tied to addiction in adults may help guide doctors to better treatments for infants born withdrawing from narcotics, according to researchers who identified the genetic link.

Babies exposed in the womb to opioid drugs who have certain variations to two genes had less severe withdrawal symptoms than those without the variants, according to a study in the Journal of the American Medical Association. The babies left the hospital sooner and needed fewer treatments, researchers said. The study, the first to look at the link between genetics and opioid withdrawal in infants, may help researchers find more effective way to treat these babies, said Jonathan Davis, senior study author and chief of newborn medicine at Floating Hospital for Children at Tufts Medical Center in Boston.”

http://www.businessweek.com/news/2013-04-30/genes-found-that-may-protect-infants-born-to-addicted-mothers

Source: BusinessWeek.com – April 30, 2013

New Poll Ranks Chronic Pain Well Below Drug Addiction As A Major Health Problem

“A new national public opinion poll commissioned by Research!America shows only 18% of respondents believe chronic pain is a major health problem, even though a majority of Americans (63%) say they know someone who experienced pain so severe that they sought prescription medicines to treat it. Chronic pain conditions affect about 100 million U.S. adults at a cost of approximately $600 billion annually in direct medical treatment costs and lost productivity.

Most Americans are concerned about the misuse of pain medication to treat chronic pain. A high percentage (82%) believes that taking prescription painkillers for long-term, chronic pain could result in addiction, which nearly 50% of Americans describe as a major health problem. An overwhelming majority (85%) are very concerned or somewhat concerned that prescription pain medication can be abused or misused. Indeed, 40% believe that prescription medication abuse and addiction is a major problem in their community.”

http://www.medicalnewstoday.com/releases/258897.php

Source: MedicalNewsToday.com – April 12, 2013

NASADAD Prescription Drug Inquiry Reveals SSAs Very Concerned About Prescription Drug Misuse and Abuse

doctor and prescription bottlePrescription drug abuse—something a whole industry of monitoring and law enforcement is growing up around—is a public health problem first, according to the state substance abuse officials responsible for treatment and prevention. That said, these same directors—the single state agencies (SSAs) with authority over the Substance Abuse Prevention and Treatment block grant—also want to participate in the prescription drug abuse conversation, explains Rob Morrison, executive director of the National Association of State Alcohol and Drug Abuse Directors (NASADAD).

Based on an inquiry of its entire membership, NASADAD staff found that single state agencies consider prescription drug misuse and abuse very important—for some, the most important—issue they face. The inquiry took place last year and was released in fall of 2012.

Forty-seven states responded to the inquiry, which yielded the following results:

  • Prescription drugs are the most important issue affecting states (23%), very important (58%), or important/moderately important (19%)
  • Of the states surveyed,
    • 62% currently have a task force addressing prescription drugs
    • 15% had a task force on prescription drugs that completed its work
    • 68% passed legislation in the past 5 years addressing prescription drug misuse and abuse
    • 83% have undertaken education efforts about prescription drug abuse for the general public
  • Among states with prescription drug monitoring programs (PDMPs),
    • 54% have some single state agency (SSA) involvement with the PDMP
    • 43% have no SSA involvement with the PDMP
    • 64% find PDMP data very useful or useful
    • 13% describe the data as somewhat useful in addressing prescription drug abuse issues

There are continued challenges to SSAs trying to address prescription drug misuse and abuse “related to data, funding constraints, collaboration, workforce development, public education, and ease of access to pills,” according to the report. It found that “although PDMPs and the data they provide are useful to SSAs, the level of oversight, access, and involvement of SSAs continues to be limited.”

Great emphasis has been placed on addressing the utility of PDMPs, but it’s important for the SSAs, as the public health and treatment experts, to be involved. SSAs would like to have more oversight, access, and involvement with PDMPs, according to the report.

In only three states—Vermont, Maine, and Maryland—is the PDMP operated under the purview of the SSA, and the agency could use the information to help get people who are misusing or abusing medications into appropriate treatment. “We have a steep growth curve here,” says Henrick Harwood, research director of NASADAD. “We need to increase the education so prescribers can help people get into treatment.”

The Office of National Drug Control Policy (ONDCP) has been very helpful in issuing a strategy and structure around which to build a public health approach to prescription drug abuse, says NASADAD’s Mr. Morrison.

 Connection to MAT

There is a clear connection between prescription opioid abuse and medication-assisted treatment (MAT). Many patients newly admitted to treatment are dependent on opioids—either because they started taking them for pain, then began misusing them, or abused them from the beginning. When they try to stop, they go into withdrawal. So some states have increased training for treatment staff, in particular on prescription drug abuse and on MAT.

And there are particular challenges for states in addressing prescription drug abuse. For example, PDMP data aren’t always of good quality or easy to utilize, according to the report. And substance use disorder treatment providers don’t always have a way to access it. There is also a dearth of financial resources, with lack of adequate funding for MAT and lack of funding for naloxone overdose kits, a promising public health response to overdoses, according to the report. And there are problems with states’ proposing to restrict MAT funding.

The NASADAD report is available at: http://nasadad.org/wp-content/uploads/2012/10/NASADAD-Report-SSAs-and-Prescription-Drug-Misuse-and-Abuse-09.20121.pdf

Parents Numb to Misuse of Narcotic Pain Meds by Youth, New Poll Shows

Despite data on rising rates of abuse and overdoses of narcotic pain medicines across all age groups, in a new poll from the University of Michigan, most parents said they are not very concerned about misuse of these medicines by children and teens.

In addition, parent support was lukewarm for policies that would discourage abuse of drugs like Vicodin or Oxycontin, according to the most recent University of Michigan Mott Children’s Hospital National Poll on Children’s Health.

Report highlights include:

  • ¨About one-third of parents report they had received at least one pain medicine prescription for their children in the last five years.
  • ¨35% of parents are very concerned about misuse of narcotic pain medicines by children and teens in their communities; only 19% are concerned about misuse in their families.
  • ¨Nearly one-half of parents do not favor a requirement that they return unused pain medicine to the doctor or pharmacy.

The press release is available at: http://www.newswise.com/articles/parents-numb-to-misuse-of-narcotic-pain-meds-by-youth-new-poll-shows

Source: Newswise/University of Michigan Health System – January 23, 2013

Researchers Say MRI Could Help Predict Success of Drug Addiction Treatment

Scientists at the University of Pennsylvania say MRI scans may be able to predict which patients will succeed with certain addiction treatments, and which ones will relapse, according to the Philadelphia Daily News.

Researchers at the university’s Center for Studies of Addiction are watching how regions of the brain react to drug-related photos, such as pictures of a heroin needle or a crushed pill. They hope to use this research to develop more effective treatments. One day, they hope that treatment could be tailored to a person’s mental strengths and vulnerabilities. These factors are influenced by genetics, life experiences and drug use, they say.

http://www.drugfree.org/join-together/addiction/researchers-say-mri-could-help-predict-success-of-drug-addiction-treatment?utm_source=Join+Together+Weekly&utm_campaign=16753ecc0b-

Source: JoinTogether.org – January 18, 2013

U.S. Military Working on Combination Anti-Heroin/HIV Vaccine

A scientist at the Walter Reed Army Institute of Research is developing a vaccine designed to treat heroin addiction while at the same time prevent HIV infection. This project is one of a number of research initiatives around the world that are working toward new vaccines to fight addiction.

The National Institute on Drug Abuse recently pledged $5 million toward Dr. Gary Matyas’ work on the new dual vaccine. The goal of the vaccine is to fight heroin abuse and the high risk of HIV infection among heroin users who inject the drug.

 http://www.drugfree.org/join-together/addiction/u-s-military-working-on-combination-anti-heroinhiv-vaccine

Source:  JoinTogether.org – November 30, 2012

Report Says Adults Who Had Mental Illness in the Past Year Were More Than Three Times as Likely to Have Met the Criteria for Substance Dependence or Abuse

One in 5 American adults aged 18 or older, or 45.6 million people, had mental illness in the past year, according to a report from the Substance Abuse and Mental Health Services Administration (SAMHSA).

The 2011 National Survey on Drug Use and Health (NSDUH): Mental Health Findings report presents results pertaining to mental health from the 2011 NSDUH, the primary source of statistical information on the use of illegal drugs, alcohol, and tobacco by the civilian, noninstitutionalized population of the United States aged 12 years or older. Conducted by the federal government since 1971, the survey collects data through face-to-face interviews with approximately 65,750 people aged 12 years or older nationwide, at the respondent’s place of residence.

According to the report, rates for substance dependence or abuse were far higher for those who had mental illness than for the adult population which did not have mental illness in the past year. Adults who had mental illness in the past year were more than three times as likely to have met the criteria for substance dependence or abuse in that period than those who had not experienced mental illness in the past year (17.5 percent versus 5.8 percent). Those who had serious mental illness in the past year were even more likely to have had substance dependence or abuse (22.6 percent).

The complete survey findings from this report are available on the SAMHSA Web site at http://www.samhsa.gov/newsroom/advisories/1211273220.aspx

Source: The Substance Abuse Mental Health Services Administration – November 27, 2012

Decrease in Nonmedical Use of Prescription Drugs Among U.S. Residents Fueled by Decrease in Pain Reliever Use

While the nonmedical use of prescription drugs continues to be the second most commonly used illicit drug among U.S. residents, the number of past year users recently declined for the first time since 2008 (see CESAR FAX, Volume 21, Issue 40). According to data from the National Survey on Drug Use and Health (NSDUH), the decline was driven by a decrease in the nonmedical use of pain relievers. In 2011, 14.7 million U.S. residents reported the nonmedical use of prescription pain relievers, down from the most recent peak of 16.5 million in 2006.

Decreases in nonmedical use of pain relievers occurred among youth (12 to 17 years old) as well as young adults (18 to 25), while use among adults ages 26 or older has remained unchanged for the past ten years (data not shown). The only other prescription drug to decrease from 2010 to 2011 was the nonmedical use of sedatives, which decreased from 906,000 to 526,000—primarily due to a decrease in use by adults ages 26 or older.

Estimated Number (in thousands) of Past Year Users of Prescription Drugs Used Nonmedically,
U.S. Residents Ages 12 and Older, 2002-2011

Need to insert chart

The difference between the 2010 and 2011 estimate is statistically significant at p < 0.05.

NOTES: While the NSDUH (previously named the National Household Survey on Drug Abuse) has been conducted since 1971, the survey underwent several methodological improvements in 2002 that affected prevalence estimates. As a result, the 2002 through 2010 estimates are not comparable with estimates before 2002.

Nonmedical Use of Prescription Drugs is defined as use of pain relievers, tranquilizers, stimulants, and/or sedatives without a prescription belonging to the respondent or use that occurred simply for the experience or feeling the drug caused. It does not include the use of over-the-counter drugs.

The complete survey findings are available on the SAMHSA website at: http://www.samhsa.gov/data/NSDUH/2k11Results/NSDUHresults2011.pdf

Source: CesarFax.com – October 15, 2012

PMPs Need to be More ‘User-Friendly’ for Physicians, Study Finds

There are barriers to prescribers’ use of prescription monitoring programs (PMPs), according to researchers from the American College of Medical Toxicology (ACMT). In a June 21 New England Journal of Medicine Perspective article, Jeanmarie Perrone, MD, and Lewis Nelson, MD, found that PMPs, with some simple improvements, could be much more useful to physicians.

The most frustrating aspect of PMPs is the time it takes to use these programs. “Even if it takes only three minutes per patient, in a busy emergency department or office practice, having to do this multiple times daily amounts to a substantial time investment,” said Dr. Lewis in a press release from the ACMT. Much of the time is spent navigating to the correct web portal, they found. The physicians need to recall the password—and reset it. And many physicians found that once they did gain access, up-to-date information was not available for each patient.

Because time is the major barrier to physician use of PMPs, it would be helpful to have programs be more user-friendly, the researchers found.

Despite the barriers, the potential benefits of PMPs are great, the researchers said, noting that with enhancements to systems, these programs may help reduce prescription drug abuse.

For the research, Drs. Perrone and Lewis looked at opioid prescribing practices of ACMT members, and presented their results at the March national meeting.

For the free full-text article, go to http://www.nejm.org/doi/full/10.1056/NEJMp1204493

RI Hospital: Use of PMP May Increase Demand for Drug Treatment, Reduce Painkiller Abuse

A Rhode Island Hospital researcher has found that the use of electronic prescription drug monitoring programs (PMPs) may have a significant impact on the demand for drug treatment programs and how prescribers detect and respond to abuse of painkillers. The study by Traci C. Green, PhD, MSc, research scientist in Rhode Island Hospital’s department of general internal medicine is published in the journal Pain Medicine.The study found that prescribers’ use of an electronic PMPs may influence medical care and decisions, especially with opioid abuse detection, and is associated with clinical responses to suspected doctor shopping or diversion.

When prescribers suspected a patient of doctor shopping or diverting medications, PMP users were more likely to ramp up clinical monitoring with urine drug screens or refer the patient to drug treatment. PMP users were also less likely to ignore the warning signs or to call law enforcement.

“One thing is clear,” Green said, “Clinicians, not law enforcement, have the medical and behavioral health care expertise to guide patients struggling with addiction to get the help they need, when they are ready for it. PMPs can be an important clinical tool to address possible addiction issues and start that conversation.”

Green added, “Our study suggests that if states want wider use of PMPs by their prescribers, we need to increase access to drug treatment, especially opioid-dependence treatment options, if we are going to make headway on the epidemic of painkiller abuse and overdose death in our communities.”

http://www.rhodeislandhospital.org/wtn/Page.asp?PageID=WTN000287

Source: – Lifespan – August 16, 2012

Research: Availability of Viral Hepatitis Services in U.S. Drug Treatment Programs

The prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) is disproportionately high among individuals in U.S. drug treatment programs. Therefore, such programs are ideal settings for the provision of services targeting viral hepatitis, including screening, education, vaccine prevention, and treatment. This National Institute of Drug Abuse Clinical Trials Network (NIDA-CTN) study assessed the availability and comprehensiveness of viral hepatitis services within US drug treatment programs. Administrators from 319 drug treatment programs within the NIDA-CTN were invited to participate via survey, and 84% responded. Data were compared between programs that provided methadone (n=89) and those that did not (n=180). Most programs were private, not-for-profit, free-standing facilities but varied in most other aspects (e.g., geographic location, program size, and medical versus nonmedical staffing).

Testing for HCV-antibody was performed in 28% of programs and was more likely to be offered at methadone programs (55%) compared with programs that did not provide methadone (15%).

Vaccination for hepatitis A virus and HBV were offered either on-site or through contractual agreement with another provider in 68% of programs.

For all substance abuse treatment programs, HCV-related treatment was provided either on-site or through contractual agreement at 29% of programs and was more common in programs providing methadone than in programs that did not provide methadone (48% versus 22%, respectively). Fifteen percent of programs offered on-site HCV treatment, 3.5% offered treatment through contractual agreement with another provider, 67% referred patients to a community resource, and 15% did not offer treatment at all.

Comments: Less than one-third of drug treatment facilities offered HCV-antibody testing or HCV treatment either on-site or through contractual agreement with another provider. Programs that provided methadone were more likely to provide these services than programs that did not provide methadone. These data are likely biased in that they reflect programs enrolled in the NIDA-CTN, a group of programs that may be more likely to provide such services, and are limited by their self-report nature. The findings suggest a need to improve access to HBV and HCV screening and treatment at drug treatment programs to address this public health agenda.

Source: Alcohol, Other Drugs, and Health: Current Evidence – May/June 2012, Jeanette M. Tetrault, MD

Original Source: Bini EJ, Kritz S, Brown LS Jr, et al. Hepatitis B virus and hepatitis C virus services offered by substance abuse treatment programs in the United States. J Subst Abuse Treat. 2012;42(4):438–445.

New Report Addiction Medicine: Closing the Gap between Science and Practice

CASA Columbia’s new five year national study reveals that addiction treatment is largely disconnected from mainstream medical practice.  While a wide range of evidence-based screening, intervention, treatment and disease management tools and practices exist, they rarely are employed.  The report exposes the fact that most medical professionals who should be providing treatment are not sufficiently trained to diagnose or treat addiction, and most of those providing addiction treatment are not medical professionals and are not equipped with the knowledge, skills or credentials necessary to provide the full range of evidence-based services, including pharmaceutical and psychosocial therapies and other medical care.

The report, Addiction Medicine: Closing the Gap between Science and Practice,  examines the science of addiction–a complex disease that involves changes in the structure and function of the brain–and the profound gap between what we know about the disease and how to prevent and treat it versus current health and medical practice.

Highlights from the report include:

  • Forty million Americans ages 12 and older (16 percent) have the disease of addiction involving nicotine, alcohol or other drugs, a disease affecting more Americans than heart conditions, diabetes or cancer; another 80 million people are risky substance users – using tobacco, alcohol and other drugs in ways that threaten health and safety.
  • About 7 in 10 people with diseases like hypertension, major depression and diabetes receive treatment; only about 1 in 10 people who need treatment for addiction involving alcohol or other drugs receive it while the number receiving treatment for nicotine is not even known.
  • Addiction treatment facilities and programs are not adequately regulated or held accountable for providing treatment consistent with medical standards and proven treatment practices.
  • In 2010 only $28 billion was spent to treat the 40 million people with addiction.  In comparison, the United States spent:
    • $44 billion to treat diabetes which affects 26 million people;
    • $87 billion to treat cancer which affects 19 million people;
    • $107 billion to treat heart conditions which affect 27 million people.

The report offers a comprehensive set of recommendations to overhaul current intervention and treatment approaches and to bring practice in line with the scientific evidence and with the standard of care for other public health and medical conditions.

Press release is available at: http://www.casacolumbia.org/templates/PressReleases.aspx?articleid=680&zoneid=95

Additional study resources are available at:  http://www.casacolumbia.org/templates/NewsRoom.aspx?articleid=678&zoneid=51

Time magazine response to the report is available at: http://healthland.time.com/2012/06/26/addiction-treatment-in-america-not-based-on-science-not-truly-medical/

Source: CasaColumbia.org – June 26, 2012

Take-Home Methadone Maintenance Treatment Associated With Decreased Hospital Admissions

hospital signPatients in methadone maintenance patients that exhibit treatment successes, including regular attendance at clinic and counseling sessions, as well as passing urine screenings for illicit drug use, are rewarded with “take home” methadone doses. Previous studies have shown that receiving “take home” doses and receiving doses of 80 milligrams or more are associated with improved addiction treatment outcomes, but the impact of these factors on hospitalizations was unknown.

To explore these questions, the researchers performed a retrospective analysis of 138 patients enrolled in the Boston Public Health Commission’s MMT program for a period of two years between 2006 and 2008. The results showed that patients receiving “take home” methadone doses were substantially less likely to be admitted to the hospital with 74 percent lower odds of hospitalization. The data also showed no evidence that the dose of methadone was associated with hospitalization.

http://www.medicalnewstoday.com/releases/246641.php

Source: MedicalNewsToday.com – June 18, 2012

Mental Health Woes Raise Odds for Prescription Painkiller Abuse

Teens and young adults with mental health disorders are at increased risk for long-term use of prescription painkillers such as Vicodin and Oxycontin, according to a new study.

Researchers examined data from more than 62,000 young people, aged 13 to 24, in the Western, Midwestern and Southwestern United States. Those with mental health disorders were more likely to be prescribed opioids for chronic pain and 2.4 times more likely to become long-term opioid users than those without mental health disorders.

http://health.usnews.com/health-news/news/articles/2012/06/08/mental-health-woes-raise-odds-for-prescription-painkiller-abuse

Note: See related blog De-stigmatizing Mental Illness Is a Critical Step in New Focus on Treatment vs. Punishment for Addiction available at http://www.huffingtonpost.com/david-sack-md/destigmatizing-mental-ill_b_1594767.html

Source: HealthDay News – June 8, 2012

Data Suggests Drug Treatment Can Lower U.S. Crime

U.S. crime statistics show illegal drugs play a central role in criminal acts, providing new evidence that tackling drugs as a public health issue could offer a powerful tool for lowering national crime rates, officials said on Thursday.

Based on thousands of arrestee interviews and drug tests, the study showed that on average 71 percent of men arrested in 10 U.S. metropolitan areas last year tested positive for an illegal substance at the time they were taken into custody.

According to Dr. Redonna Chandler of the National Institute on Drug Abuse, 5 million of an estimated 7 million Americans who live under criminal justice supervision would benefit from drug treatment intervention. But only 7.6 percent actually receive treatment.

The 2011 Adam II Annual Report can be accessed at: http://www.whitehouse.gov//sites/default/files/email-files/adam_ii_2011_annual_rpt_web_version_corrected.pdf

http://www.reuters.com/article/2012/05/17/us-usa-drugs-idUSBRE84G06G20120517

Source:  Reuters.com – May 17, 2012

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