“A recent double-blind randomized controlled study by Law and colleagues published in the Journal of Psychopharmacology investigated the use of two pharmacological treatment programs to help reduce the severity of symptoms experienced by opiate-dependent individuals during stabilization and the withdrawal phase and assist them to complete detoxification.
Eighty opiate-dependent individuals were recruited for the trial between the ages of 16 – 65 years (male and female) who had been self-administering prescribed or illicit opiates (equivalent to a quarter gram of heroin intravenously) and diagnosed as opiate dependent for less than three years in total.
Lofexidine and buprenorphine/naloxone have both been shown to be effective treatments for opiate withdrawals but with different mechanisms of action. This was the first study to directly compare the treatment outcomes of administering lofexidine after methadone and buprenorphine/naloxone for detoxification in opiate-dependent individuals.”
Source: MedicalNewsBulletin.com – September 29, 2017