Note: Data in the bullet points below was corrected April 9, 2015 at 7:34 AM CST.
Despite the growing prevalence of prescription opioid dependence, longitudinal studies have not examined long-term treatment response.
This study examined outcomes over 42 months in the Clinical Trials Network Prescription Opioid Abuse Treatment Study (POATS, CTN-0030) to see what, if any, improvements in abstinence from opioids was seen over a longer term.
The original POATS study was a multi-site clinical trial lasting up to 9 months, examining different durations of buprenorphine-naloxone plus standard medical management for prescription opioid dependence. A subset of participants (375 of 653) enrolled in this follow-up study.
Telephone interviews were given approximately 18, 30, and 42 months after main-trial enrollment.
Results found that at Month 42, much improvement was seen:
- 31.7% were abstinent from opioids and not on agonist therapy;
- 29.4% were receiving opioid agonist therapy but met no symptom criteria for current opioid dependence;
- 7.5% were using illicit opioids while on agonist therapy;
- 31.4% were using opioids without agonist therapy.
Source: Clinical Trials Network Dissemination Library – March 2015